Can COVID-19 Promote Tumor Development in Patients With Cancer?

The current findings could help to explain the observed worse outcomes in patients with cancer infected with SARS-CoV-2, particularly in those with hematologic malignancies, and suggest the need for increased vigilance of patients as part of the ongoing follow-up of COVID-19…, COVID-19 May Promote Tumor Development in Patients With Cancer, Liam Davenport, 2021

Cancer-related inflammation, orchestrated by CCGs, has been shown to play an important role in the progression of both solid and hematologic cancers, including the proliferation and survival of malignant cells, angiogenesis, and metastasis.

Unexposed patients with cancer were found to have increased levels of 35 CCGs compared with unexposed healthcare workers with no significant differences between patients with solid and hematologic cancers.

Exposed patients with cancer were found to have seven CCGs that were additionally significantly altered compared with healthcare workers. Of these, TNF-alpha, IFN-beta, TSLP, and sVCAM-1, which were elevated in patients with hematologic cancers, are known tumor-promoting factors.